Large-Scale Meta-Analysis of Shared Genetic Risk for IBS and Psychiatric Disorders

A meta-analysis of genome-wide association studies (GWAS) integrated summary statistics from the UK Biobank, Bellygenes, and the Million Veteran Program. The work identified up to ten previously unreported IBS loci and over 100 pleiotropic loci shared with psychiatric traits. The dataset was authored by Weiyi Ye and last updated on May 14, 2026.

Use Cases

• Identify novel genetic loci associated with irritable bowel syndrome based on the large-scale meta-analysis.
• Investigate shared genetic mechanisms between IBS and psychiatric traits like major depressive disorder using genetic correlation analyses.
• Explore potential regulatory mechanisms for identified loci by integrating transcriptomic, methylomic, and eQTL data.
• Conduct follow-up analyses on pleiotropic loci at genes such as SORCS1, SLC35D1, COA1, and TLE1.

Strengths

• Integrates GWAS summary statistics from three major sources: UK Biobank, Bellygenes, and the Million Veteran Program.
• Identified up to ten novel IBS loci and over 100 pleiotropic loci shared with psychiatric traits.
• Released under a CC-BY-4.0 license, permitting broad reuse with attribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is limited to individuals of European ancestry, which may limit generalizability.

Provenance

Source

figshare

Collection Method

Large-scale meta-analysis and cross-trait analyses of GWAS summary statistics.

Freshness

Last updated 2026-05-14 05:43:28; freshness should be verified.

Geography

Individuals of European ancestry.