LGMN in Pulmonary Fibrosis: Macrophage-Fibroblast Crosstalk and Gene Signature

A 17.4 KB DOCX file authored by Yuechong Xia and last updated in April 2026. The document details a study analyzing single-cell transcriptomic and microarray data from the GEO database to investigate idiopathic pulmonary fibrosis (IPF). It identifies a gene signature based on monocyte-derived macrophages and explores LGMN as a potential therapeutic target.

Use Cases

• Developing prognostic models for IPF based on the described monocyte-derived macrophage gene signature.
• Investigating macrophage-fibroblast interactions in fibrotic diseases using the CellChat analysis methodology mentioned.
• Identifying potential therapeutic targets like LGMN for pulmonary fibrosis treatment.
• Analyzing TGF-β1 signaling pathway activation in specific cell types as described in the results.

Strengths

• The study methodology is detailed, including analysis of single-cell transcriptomic and microarray data.
• Findings are validated using ROC curves and an external dataset, as stated in the methods.
• Includes in vivo and in vitro experimental validation of the biological function of LGMN.

Limitations

• The dataset is a 17.4 KB DOCX file, indicating limited raw data scope; likely contains processed results and text.
• Row count and column-level documentation are absent; data structure must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, author Yuechong Xia

Collection Method

Analysis of single-cell transcriptomic and microarray data from the GEO database, supplemented with in vivo and in vitro experiments.

Time Range

Study period not specified; data likely reflects the time of the original analysis.

Freshness

Last updated 2026-04-13 04:35:55; freshness should be verified.

Geography

Geographic coverage of the patient data is not specified.