Licochalcone A Effects on Cisplatin Nephrotoxicity: In Vivo and In Vitro Study Data

A 19.2 KB Excel dataset from a 2026 study by Mo Han, shared on figshare under a CC-BY-4.0 license. It contains results from in vivo murine and in vitro HK-2 cell models investigating Licochalcone A's protective effects against cisplatin-induced kidney damage. The data likely includes measurements of renal function, oxidative stress, ferroptosis markers, and mitochondrial health.

Use Cases

• Validate the protective role of Licochalcone A against cisplatin nephrotoxicity based on renal function and histology data.
• Analyze the relationship between ferroptosis markers (Fe2+, GSH, MDA) and kidney injury outcomes.
• Investigate the Nrf2/GPX4 pathway's involvement in drug protection using molecular docking and protein binding affinity data.
• Model the transition from acute to chronic kidney disease using tubular injury and fibrosis progression metrics.

Strengths

• Data is associated with a detailed experimental methodology described in the publication, including in vivo and in vitro models.
• The dataset is openly available under a permissive CC-BY-4.0 license.
• Last updated on 2026-04-17, indicating recent curation.

Limitations

• The dataset is very small at 19.2 KB, suggesting limited scope or a summary of key results.
• Column names and row counts are unknown, making pre-download assessment of data structure difficult.
• The description focuses on biological conclusions; specific data variables and their formats must be inspected after download.

Provenance

Source

figshare, uploaded by author Mo Han.

Collection Method

Experimental data from murine models and HK-2 cell cultures, analyzed via staining, assays, and metabolomics.

Freshness

Last updated 2026-04-17 05:08:40.