Limited Adaptability of Virtual Memory CD8 T Cells to Chronic Viral Infection

A 12.2 KB Excel file from a 2026 study by Yamato Sajiki on figshare. It contains data from a chronic lymphocytic choriomeningitis virus infection model in mice. The dataset likely compares the responses of virtual memory and naïve CD8 T cells to persistent antigen stimulation.

Use Cases

• Compare T cell subset responses based on the described differences between virtual memory and naïve CD8 T cells.
• Analyze gene expression patterns related to the T cell exhaustion program and TOX expression.
• Investigate the differentiation of KLRG1+PD-1- cell populations in different T cell progenitors.
• Study the correlation between TCF1+ stem-like cell frequency and response to PD-1 blockade therapy.

Strengths

• Data is openly available under a CC-BY-4.0 license.
• The study provides a specific mechanistic focus on TOX expression and TCF1+ stem-like cells.
• File size of 12.2 KB suggests a focused, potentially curated dataset.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The dataset is very small (12.2 KB), indicating limited scope and scale.
• Data is derived from a specific mouse infection model, which may limit generalizability.

Provenance

Source

figshare, author Yamato Sajiki.

Collection Method

Likely generated from a chronic lymphocytic choriomeningitis virus infection mouse model experiment.

Freshness

Last updated 2026-05-22 09:48:24.