Zebrafish shox/shox2 Gene Expression Data Linked to fgfr3 and Natriuretic Peptides

A 23.4 KB dataset from figshare, authored by Sandra Hoffmann and last updated on 2026-04-17. It contains experimental results linking shox and shox2 gene deficiencies to fgfr3 expression and natriuretic peptide activity in zebrafish embryos, fins, heart, and brain tissues. The data supports research into vertebrate developmental processes and potential human clinical implications.

Use Cases

• Analyze tissue-specific gene expression patterns based on shox and shox2 knockdown experiments described.
• Investigate relationships between shox2 deficiency and fgfr3 levels as indicated in the description.
• Study the regulation of natriuretic peptide genes (nppa, nppb, nppc) in response to shox/shox2 alterations.
• Model additive, synergistic, or antagonistic gene interactions in different embryonic tissues.
• Explore markers for cardiac stress based on nppb expression changes in heart tissue.

Strengths

• Data is associated with a specific, peer-reviewed research context described in detail.
• The dataset is licensed under CC-BY-4.0, allowing for open reuse and modification.
• File size is 23.4 KB, indicating a focused and manageable dataset.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The dataset is stored as a DOCX file, which may require conversion for typical data analysis workflows.
• Data may reflect experimental bias inherent to the specific zebrafish model and methodology used.

Provenance

Source

figshare, author Sandra Hoffmann.

Collection Method

Likely contains experimental results from zebrafish gene expression studies, including knockdowns and transcript level measurements.

Freshness

Last updated 2026-04-17 04:11:51; freshness should be verified.