AC245100.4: Serum Exosomal RNA Biomarker for Acute Pancreatitis Diagnosis and Prognosis

228 participants, including 152 acute pancreatitis patients and 76 controls, were enrolled during early admission. Serum exosomal long non-coding RNA AC245100.4 expression was measured and evaluated for its diagnostic and prognostic value in severe acute pancreatitis and persistent organ failure. The dataset, authored by Jie Chen and last updated in May 2026, likely contains clinical and molecular assay results supporting the biomarker's role in inflammation-regulatory mechanisms.

Use Cases

• Developing early diagnostic models for acute pancreatitis based on serum exosomal RNA levels.
• Prognostic risk stratification for severe acute pancreatitis and persistent organ failure based on biomarker expression.
• Investigating inflammation-related cellular communication pathways involving acinar cells and macrophages.
• Evaluating the additive value of a molecular biomarker to established clinical scoring systems.

Strengths

• Includes data from 228 participants, providing a defined cohort size.
• Samples were collected within a standardized early window (within 24 hours of admission and 48 hours of symptom onset).
• Biomarker performance is quantified with reported AUCs ranging from 0.84 to 0.88.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 13.3 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Clinical study involving serum sample collection, exosome isolation, and quantitative reverse-transcription polymerase chain reaction.

Freshness

Last updated 2026-05-01 05:27:29; freshness should be verified.