Long-Term Survival Outcomes for T4N0-3M0 Esophageal Cancer Treatments

From 2011 to 2018, a single-center retrospective cohort study compared two treatment regimens for 490 patients with T4N0-3M0 esophageal squamous cell carcinoma. The data includes 108 patients treated with surgery plus adjuvant chemoradiotherapy and 382 treated with definitive chemoradiotherapy, with survival outcomes analyzed before and after propensity score matching.

Use Cases

• Compare Overall Survival (OS) and Progression-Free Survival (PFS) metrics between the S+CRT and dCRT treatment groups.
• Apply propensity score matching (PSM) analysis to the patient cohort data to control for selection bias in treatment assignment.
• Analyze long-term prognostic outcomes for the specific T4N0-3M0 stage of esophageal squamous cell carcinoma.

Strengths

• Dataset contains records for 490 patients with a specific cancer stage (T4N0-3M0 ESCC).
• Includes a direct comparison of two distinct treatment regimens (S+CRT vs. dCRT) with statistical significance reported for survival outcomes.
• Analysis was performed both on the full cohort and on a propensity score-matched subset of 219 patients (138 dCRT, 81 S+CRT).

Limitations

• Limited to 33.5 KB, indicating the dataset is likely a summary table or document, not the underlying patient-level clinical data.
• Single-center study design may limit generalizability of findings to other populations or healthcare settings.
• Retrospective observational study is subject to potential confounding factors despite use of propensity score matching.

Provenance

Source

Single-center retrospective cohort study by author Shiwang Wen.

Collection Method

Patient records reviewed for those receiving specified treatments between January 2011 and December 2018.

Time Range

January 2011 to December 2018.

Freshness

Data covers patients treated up to December 2018; metadata was last updated in March 2026.

Geography

Patients treated at a single, unspecified institution; geographic coverage is null.