Longitudinal Human Milk Oligosaccharide Profiles in Japanese Mothers

The Chiba Study of Mother and Child Health (C-MACH) collected 570 human milk samples from 270 Japanese mothers at colostrum, 1 month, and 4 months postpartum. Naoko Higuchi quantified 15 major human milk oligosaccharides (HMOs) and classified mothers into four Secretor/Lewis phenotype groups. The dataset, last updated in 2026, captures longitudinal HMO concentration changes and exploratory associations with maternal and infant characteristics.

Use Cases

• Analyze longitudinal concentration trends of 15 major HMOs based on lactation stage.
• Compare HMO profiles across four Secretor/Lewis phenotype groups (Se+Le+, Se+Le-, Se-Le+, Se-Le-).
• Investigate associations between HMO concentrations and maternal characteristics like parity.
• Model infant gut microbiota development based on fucosylated, acetylated, and sialylated HMO levels.

Strengths

• 570 samples provide a longitudinal view across three lactation stages (colostrum, 1 month, 4 months).
• Includes classification of 270 mothers into four distinct Secretor/Lewis phenotype groups.
• Quantifies 15 major HMOs, enabling detailed compositional analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is geographically specific to Japan, which may limit generalizability.

Provenance

Source

Chiba Study of Mother and Child Health (C-MACH)

Collection Method

Human milk samples were collected and 15 major HMOs were quantified.

Time Range

Samples collected at colostrum, 1 month, and 4 months postpartum.

Freshness

Last updated 2026-05-28 09:43:26

Geography

Japan