Longitudinal Mouse Data on Lung Injury and Gut Microbiome Disruption

A mouse model study integrates longitudinal data on lung pathology, lung function, gut microbiome, and serum metabolomics. The 9.6 KB Excel file contains results from an 8-week cigarette smoke exposure followed by 15 days of influenza A virus infection monitoring. Author Zhihang Liu published the supporting data via figshare in April 2026.

Use Cases

• Correlate gut microbiota abundance, such as Intestinimonas, with pulmonary inflammatory markers like immune cell recruitment.
• Analyze temporal changes in serum unsaturated fatty acid biosynthesis pathway metabolites from day 3 to day 15 post-infection.
• Validate the biomarker potential of 1-Methylnicotinamide (1-MNA) identified via random forest modeling for distinguishing acute exacerbation stages.
• Examine relationships between lung function metrics, emphysematous changes, and concurrent shifts in fecal metabolome profiles.
• Model the longitudinal trajectory of interstitial immune cell infiltration and collagen deposition against dynamic microbiome composition.

Strengths

• Longitudinal assessment spans 15 days post-infection with measurements at multiple time points.
• Integrates four distinct data modalities: lung pathology, lung function, gut microbiome (16S rRNA), and metabolomics (serum and fecal).
• Includes a validated biomarker (1-MNA) with a reported AUC of 1.0 from random forest analysis.

Limitations

• The dataset is very small at 9.6 KB, indicating limited scope, likely summary statistics rather than raw sequencing or metabolomics data.
• Data is derived solely from a controlled mouse model, limiting direct applicability to human COPD studies.
• Specific row counts, column names, and sample-level data are unavailable, restricting detailed re-analysis.

Provenance

Source

figshare, authored by Zhihang Liu.

Collection Method

Experimental data from mice exposed to cigarette smoke for eight weeks then infected with influenza A virus, with longitudinal multi-omics analysis.

Time Range

Covers an 8-week exposure period plus 15 days post-infection monitoring.

Freshness

Last updated April 2026.

Geography

Laboratory mouse study; geographic location is null.