Longitudinal Retinal Microvascular Changes in Neuromyelitis Optica Spectrum Disorder

A longitudinal observational study of 45 aquaporin-4 antibody-positive NMOSD patients and 45 matched healthy controls. It includes Optical Coherence Tomography Angiography (OCTA) metrics and brain MRI white matter hyperintensity (WMH) burden data collected at baseline and a 1-year follow-up. The dataset was published by Yi Liu on figshare under a CC-BY-4.0 license.

Use Cases

• Modeling the association between retinal capillary density and cerebral white matter hyperintensity burden based on OCTA and MRI metrics.
• Analyzing longitudinal changes in radial peripapillary capillary and superficial vascular complex densities over a 1-year period.
• Developing diagnostic classifiers for NMOSD based on retinal microvascular features like foveal avascular zone area.
• Investigating the discriminatory performance of OCTA metrics for disease monitoring.

Strengths

• Includes a matched control group of 45 healthy subjects for comparison.
• Longitudinal design with baseline and 1-year follow-up data for tracking changes.
• Multimodal data combining OCTA retinal imaging and brain MRI (Fazekas scale) assessments.
• Specific statistical results are reported, such as AUC=0.78 for RPC density discriminatory performance.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 13.6 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Longitudinal observational study using OCTA imaging and brain MRI.

Time Range

Study includes baseline and a 1-year follow-up period.

Freshness

Last updated 2026-04-15 04:36:54; freshness should be verified.

Geography

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