LRRK2 and ArfGAP1 Phosphorylation Data from Parkinson's Disease Study

Experimental data from a study on the phosphorylation of the protein ArfGAP1 by the Parkinson's disease-linked kinase LRRK2. The dataset, 46.2 KB in size, was authored by Md. Shariful Islam and last updated on April 21, 2026. It likely contains results from in vitro assays, interactome analysis, and cellular phenotype measurements.

Use Cases

• Analyzing the effects of phospho-null and phospho-mimic mutations on ArfGAP1 activity based on the described cellular assays.
• Studying changes in protein-protein interactions, such as with mitochondrial VDAC proteins, based on the described interactome analysis.
• Investigating the relationship between LRRK2-mediated phosphorylation and subcellular localization shifts from the Golgi to the cytoplasm.
• Validating ArfGAP1 as a potential therapeutic target for LRRK2-linked Parkinson's disease based on the described functional consequences.

Strengths

• Data is associated with a specific, peer-reviewed research hypothesis on LRRK2 and ArfGAP1.
• The dataset is small (46.2 KB), facilitating quick download and initial inspection.
• It is shared under a permissive CC-BY-4.0 license, allowing for reuse with attribution.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset's 46.2 KB size indicates a very limited scope, likely containing summary or key result tables rather than raw experimental data.

Provenance

Source

figshare

Collection Method

Likely contains summarized results from molecular biology experiments, including kinase assays, mutagenesis, and protein interaction analysis.

Freshness

Last updated 2026-04-21 05:35:36; freshness should be verified.