Table 1_Lung function impairment in children post-tuberculosis treatment: a systematic rev

A systematic review and meta-analysis by Hanhan Wu, published on figshare in April 2026, summarizing evidence on lung function outcomes in children after pulmonary tuberculosis treatment. It includes nine studies, with pooled mean z-scores for FEV₁, FVC, and FEV1/FVC ratio calculated from data sourced from PubMed, Embase, Web of Science, and Scopus. The analysis indicates significant reductions in FEV₁ and FVC in children post-treatment compared to healthy controls.

Use Cases

• Estimating the magnitude of lung function impairment in children post-TB treatment based on pooled z-scores for FEV₁ and FVC.
• Comparing pulmonary function outcomes between post-TB children and healthy controls using standardized mean differences (Hedges' g).
• Assessing heterogeneity in study findings across different research contexts, as indicated by the reported I² values of 55%–98%.
• Informing clinical guidelines for post-treatment monitoring of pediatric TB patients based on the meta-analysis conclusions.

Strengths

• Includes results from nine distinct studies, providing a synthesized evidence base.
• Reports specific pooled effect sizes with 95% confidence intervals, such as FEV₁ z-score of -1.51 (95% CI -2.38 to -0.64).
• Uses a defined, reproducible methodology with a PROSPERO registration (CRD420251166413).
• Released under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.

Limitations

• The underlying data tables and column definitions are not provided, requiring inference from the manuscript.
• The dataset is a 26.7 KB document, representing a summary of findings rather than the raw, analyzable data.
• The authors note high heterogeneity (I² up to 98%) across included studies, which may affect the precision of pooled estimates.

Provenance

Source

figshare, authored by Hanhan Wu.

Collection Method

Systematic review and meta-analysis of studies from PubMed, Embase, Web of Science, and Scopus up to October 23, 2025.

Time Range

Studies included up to October 2025; publication date is April 2026.

Freshness

Last updated 2026-04-23 05:35:12; freshness should be verified.