Lymphocyte Subsets in Untreated Thalassemia Patients by Genotype and Age

Renbin Zhao's dataset, last updated in June 2026, characterizes lymphocyte subsets in 228 treatment-naïve thalassemia patients and 307 healthy controls. The data is stratified by genetic subtype (α, β, α+β) and age group (pediatric vs. adult), with measurements obtained via flow cytometry. It includes 535 total participants and was published under a CC-BY-4.0 license.

Use Cases

• Compare Tregs frequencies between thalassemia subtypes and healthy controls based on the reported statistical differences.
• Analyze age-related differences in CD3+ and CD4+ T-cell proportions among thalassemia patients.
• Investigate correlations between specific genetic mutations (e.g., Hb Constant Spring heterozygosity) and lymphocyte subset profiles.
• Benchmark immune cell distributions in treatment-naïve patient cohorts for clinical study design.

Strengths

• Includes 535 participants (228 patients, 307 controls), providing a defined cohort size.
• Stratifies data by two key variables: genetic subtype and age group.
• Reports specific statistical findings (e.g., P-values) for differences in lymphocyte subsets.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small at 29.8 KB, indicating limited scope.

Provenance

Source

figshare, author Renbin Zhao.

Collection Method

Flow cytometry was utilized to quantify peripheral blood lymphocyte subsets; genotyping was performed using NGS.

Freshness

Last updated 2026-06-03 06:04:46; freshness should be verified.