Pediatric Drug Hypersensitivity Case Series from a Tertiary Hospital

A retrospective case series from a tertiary hospital covering 2018 to 2024 analyzes 81 children with adjudicated adverse drug reactions. The data, authored by Olga Rogozina, evaluates the lymphocyte transformation test's diagnostic accuracy against re-exposure tolerance as a reference standard.

Use Cases

• Evaluate the diagnostic performance of the lymphocyte transformation test based on sensitivity and specificity metrics.
• Associate causality scores from the Spanish Pharmacovigilance System with laboratory test outcomes based on reported p-values.
• Identify common culprit drugs in pediatric adverse drug reactions based on reported frequencies like amoxicillin and paracetamol.
• Compare the utility of skin tests, drug provocation testing, and in vitro assays based on the described methodology.

Strengths

• Includes 81 pediatric cases with a mean age of 9.2 years and gender distribution.
• Reports specific diagnostic performance metrics for LTT, including 100% sensitivity and 78% specificity.
• Covers a six-year time range (2018–2024) from a defined clinical setting.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect the specific patient population and diagnostic practices of a single tertiary care hospital.

Provenance

Source

figshare

Collection Method

Retrospective case-series identified through pharmacovigilance programs and clinical referrals at a tertiary hospital.

Time Range

2018–2024

Freshness

Last updated 2026-05-15 05:42:55; freshness should be verified.