MAFLD and Bone Mineral Density in Type 2 Diabetes Patients

169 patients with type 2 diabetes were analyzed in a retrospective cross-sectional study to investigate associations between metabolic dysfunction-associated fatty liver disease (MAFLD) and bone mineral density. The study, authored by Lu Lin and posted on figshare in 2026, found MAFLD was associated with significantly lower BMD T-scores and a higher prevalence of osteopenia/osteoporosis. An exploratory mediation analysis suggested a modest indirect effect via insulin resistance (HOMA-IR).

Use Cases

• Analyze associations between fatty liver disease and bone health based on demographic, anthropometric, and metabolic data.
• Perform statistical mediation analysis to explore pathways like insulin resistance based on HOMA-IR and BMD T-score variables.
• Investigate prevalence of low bone mass (osteopenia/osteoporosis) across patient subgroups based on MAFLD status.
• Validate non-invasive fibrosis indices like FIB-4 against clinical outcomes based on the supplementary data.

Strengths

• Includes 169 patient records with detailed demographic breakdown (108 men, 61 women).
• Provides specific statistical results, including multivariable regression coefficients (β = -0.562) and mediation analysis effect sizes (β = -0.070).
• Data is openly licensed under CC-BY-4.0.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The study is a single-center, cross-sectional analysis, which limits causal inference and generalizability.

Provenance

Source

figshare

Collection Method

Retrospective cross-sectional study collecting demographic, anthropometric, metabolic, and bone mineral density data.

Freshness

Last updated 2026-05-22 04:28:17; freshness should be verified.