Table 1_Mapping the landscape of managed entry agreements: a systematic review of global f

A systematic review of 96 studies on Managed Entry Agreements (MEAs) for pharmaceuticals, conducted by Hussain Abdulrahman Al-Omar and published in 2026. The review maps global evidence on MEA policies, system-level components, and implementation challenges, with a focus on European and North American health systems. It identifies key barriers such as inefficient regulatory frameworks and data infrastructure limitations.

Use Cases

• Analyzing geographic evidence gaps in MEA research based on the review's finding of a significant gap for the Middle East and low-income countries.
• Identifying common barriers to MEA implementation based on themes like regulatory frameworks, data infrastructure, and administrative burden.
• Studying stakeholder representation in health policy based on the noted underrepresentation of academia and civil society.
• Investigating policy frameworks for Advanced Therapy Medicinal Products (ATMPs) based on the minority of studies focusing on this theme.

Strengths

• Based on a systematic review of 96 studies following PRISMA guidelines.
• Provides quantified findings, such as 43% of studies focusing on European systems and 42% identifying inefficient regulatory frameworks as a key barrier.
• Explicitly identifies a critical 'how-to' gap in the existing literature, providing clear direction for future research.

Limitations

• The dataset is a 668.4 KB DOCX document; its scope is limited to a review article and does not contain primary research data.
• Column-level documentation is absent; the content is narrative text and tables whose structure must be inferred after download.
• The geographic coverage is biased towards European and North American systems, as noted in the review's results.

Provenance

Source

figshare

Collection Method

Systematic review conducted following PRISMA guidelines, searching MEDLINE and EMBASE from inception to March 2025.

Time Range

Literature review covering studies from database inception to March 2025.

Freshness

Last updated 2026-04-20 05:23:22.

Geography

Global focus, but included studies were predominantly from European (43%) and North American (28%) systems.