Maternal Probiotic Supplementation Umbrella Review Outcomes

An umbrella review re-analyzes 18 systematic reviews on maternal probiotic supplementation and offspring health. The analysis encompasses 62 specific offspring-related outcomes, with summary effects re-estimated using random-effects models. The dataset presents findings on outcomes like eczema risk and breast milk microbiota, graded for evidence certainty and credibility.

Use Cases

• Analyze GRADE certainty ratings across the 62 offspring-related outcomes to identify evidence gaps.
• Compare re-estimated summary effects (e.g., RR, SMD) for outcomes like eczema risk and pathogenic bacteria abundance.
• Examine AMSTAR-2 quality appraisal scores across the 18 included systematic reviews.
• Investigate sensitivity analysis results showing significance loss for 65% of associations.

Strengths

• Re-analysis of 18 systematic reviews provides a consolidated evidence base.
• Focuses on 62 specific offspring-related health outcomes from meta-analyses.
• Evidence is appraised with standardized tools (AMSTAR-2, GRADE).
• Open CC BY 4.0 license facilitates academic reuse.

Limitations

• The dataset is small (178.1 KB), indicating limited raw data or summary tables only.
• All statistically significant associations were rated as having weak credibility per the review.
• Input structure (columns, rows) is unknown, limiting immediate analytical utility.

Provenance

Source

figshare, authored by Wenrui Sun.

Collection Method

Umbrella review with re-analysis of systematic reviews and meta-analyses from PubMed, Embase, CINAHL, Web of Science, and Cochrane Library.

Time Range

Literature search covered studies up to June 15, 2025.

Freshness

Last updated March 2026, based on literature search up to June 2025.

Geography

Global scope of included systematic reviews.