Changma Xifeng Tablet Mechanisms in Tourette Syndrome Murine Model

A 2026 study by Yuanyang Shao on figshare investigates the mechanisms of Changma Xifeng tablet in a Tourette syndrome murine model. The dataset likely contains results from behavioral assessments, ELISA, RT-qPCR, Western blot, and serum metabolomics analyses. It includes findings on 21 identified chemical components and 398 differentially expressed metabolites.

Use Cases

• Analyze the relationship between behavioral performance and neurotransmitter levels (5-HT, DA, HVA, NE) based on ELISA results.
• Investigate gene and protein expression changes (DRD1, DRD2, COMT, MAO-B) in response to treatment based on RT-qPCR and Western blot data.
• Explore metabolic pathway alterations in lipid and organic acid metabolism based on 398 identified serum metabolites.
• Examine dose-dependent effects of a traditional Chinese medicinal formulation on inflammatory cytokines (IL-1β, IL-6).

Strengths

• Includes multi-modal experimental data: behavioral, molecular (ELISA, RT-qPCR, WB), and metabolomic (UHPLC-Q-TOF LC-MS) results.
• Identifies 21 specific chemical components in the Changma Xifeng tablet formulation.
• Reports on 398 differentially expressed metabolites from serum metabolomics analysis.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is contained in a 21.4 KB DOCX file, suggesting a limited scope, likely a summary table rather than raw experimental data.

Provenance

Source

Yuanyang Shao on figshare.

Collection Method

Data generated from a controlled laboratory study using 60 male BALB/c mice divided into 6 groups, with TS models induced by IDPN injection.

Time Range

Study period not specified; data published in 2026.

Freshness

Last updated 2026-04-10 05:58:43; freshness should be verified.

Geography

Likely a laboratory study; geographic origin not specified.