Table 1_Mechanisms of fetal growth restriction in gestational cholestasis: role of gut microbiota and placental redox.docx

This dataset originates from a study using a murine model of intrahepatic cholestasis of pregnancy (ICP) to investigate mechanisms of fetal growth restriction. It employs multi-omics approaches including placental transcriptome sequencing, maternal gut microbiome profiling, and serum/placental metabolome analysis. The data is contained in a 670.4 KB DOCX file.

Use Cases

• Analyze placental transcriptome sequencing data to identify downregulated antioxidant-related genes like Mgst1, Gstt1, and Gpx8.
• Correlate maternal gut microbiome profiling results with levels of microbial metabolites such as valeric acid and erythritol.
• Investigate the relationship between placental oxidative stress markers like malondialdehyde (MDA) and fetal growth outcomes.
• Model the gut microbiota-placenta axis by integrating gut microbiome, metabolome, and placental transcriptome datasets.

Strengths

• Data integrates multiple omics modalities: transcriptome, microbiome, and metabolome.
• Study is based on a controlled murine model of ICP established from E0.5 to E18.5.
• Dataset is openly licensed under CC BY 4.0.

Limitations

• The dataset is small in file size (670.4 KB), indicating limited raw data scope.
• Data is presented in a DOCX document, requiring extraction for computational analysis.
• Findings are derived from a mouse model and may not directly translate to human physiology.

Provenance

Source

figshare, authored by Zhenhua Xue.

Collection Method

Generated from a controlled laboratory study using a pregnant C57BL/6 mouse model fed a 0.1% DDC diet.

Time Range

Experimental period from embryonic day 0.5 to 18.5 (E0.5 to E18.5).

Freshness

Last updated on 2026-03-20.