Melanoma Stem Cell and Macrophage Interaction Data from In Vitro Models

Transcriptomic and functional data from an in vitro study investigating how melanoma stem cells reprogram macrophages. The dataset, authored by Martina Anselmi and last updated in June 2026, includes results from melanosphere cultures, THP-1 monocyte migration assays, RNA-seq of macrophage phenotypes, and NK cell cytotoxicity tests. Exploratory clinical relevance was assessed using a melanoma patient cohort.

Use Cases

• Training models to predict macrophage phenotype based on stem cell signaling based on the described transcriptomic profiling.
• Analyzing associations between macrophage gene signatures and patient survival based on the independent melanoma cohort analysis.
• Studying the impact of conditioned media on immune cell function based on the NK-cell cytotoxicity assays.
• Investigating monocyte recruitment mechanisms in melanoma based on the CCR2 inhibition migration experiments.

Strengths

• Data is derived from standardized in vitro models using two established melanoma cell lines (A375 and WM115).
• Includes exploratory validation in an independent clinical cohort of melanoma patients.
• Dataset is openly available under a CC-BY-4.0 license.

Limitations

• The dataset is very small (17.3 KB), suggesting it contains summary or processed results rather than raw experimental data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analysis.

Provenance

Source

figshare, author Martina Anselmi.

Collection Method

Generated from laboratory experiments using melanosphere cultures, THP-1 monocyte differentiation, RNA sequencing, and functional assays.

Freshness

Last updated 2026-06-02 05:43:47; freshness should be verified.