Meta-Analysis on Rheumatoid Arthritis and Thyroid Cancer Risk from 14 Cohort Studies

Xue Li's meta-analysis, published on figshare in June 2026, aggregates findings from 14 cohort studies involving 1,970,165 participants. The study estimates the association between Rheumatoid Arthritis (RA) and the risk of developing thyroid cancer. It reports a pooled hazard ratio of 1.28 and includes subgroup analyses by population and adjustment factors.

Use Cases

• Estimating pooled cancer risk based on aggregated hazard ratios from multiple studies.
• Conducting subgroup analysis on specific populations, such as the Chinese cohort mentioned in the results.
• Comparing risk estimates under different statistical adjustment models, like parsimonious versus extended adjustment.
• Informing clinical surveillance strategies for thyroid cancer in RA patients based on the meta-analysis conclusion.

Strengths

• Aggregates data from 14 distinct cohort studies.
• Includes a total participant pool of 1,970,165 individuals.
• Provides specific statistical results, including a pooled HR of 1.28 (95% CI: 1.05-1.55).
• Registered on the PROSPERO platform (CRD420251267552), indicating a structured review protocol.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (57.9 KB), suggesting it contains summary results rather than raw study data.

Provenance

Source

figshare (author: Xue Li)

Collection Method

Systematic review and meta-analysis of studies from PubMed, EMBASE, and Web of Science up to October 2025.

Time Range

Studies from database inception to October 2025.

Freshness

Last updated 2026-06-03 08:46:19; freshness should be verified.

Geography

Global, with a specific subgroup analysis for the Chinese population.