Metabolic Profiles of PCOS-like Endometrial Organoids with Glutamine Analysis

9.5 KB of metabolomic data from a simulated polycystic ovary syndrome (PCOS) endometrial organoid model. Haoxuan Yang published this dataset on figshare in March 2026, detailing amino acid and fatty acid changes in intra- and extra-organoid fluids. The analysis highlights glutamine's role in endometrial stromal cell decidualization, suggesting potential metabolic targets for PCOS-related infertility.

Use Cases

• Identify metabolic biomarkers for PCOS-related endometrial dysfunction based on amino acid and fatty acid profiles.
• Model the impact of androgen exposure on endometrial cell metabolism using the described high-androgen organoid model.
• Investigate the role of glutamine in mitochondrial function during the implantation process as described in the study.

Strengths

• Data is openly licensed under CC-BY-4.0.
• The dataset is based on a described high-throughput quantitative metabolomics analysis.
• The model includes three cases of endometrial organoids derived from clinically healthy endometrium.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 9.5 KB, indicating limited scope.

Provenance

Source

figshare, author Haoxuan Yang.

Collection Method

Metabolomic analysis of intra-organoid fluid (IOF) and extra-organoid fluid (EOF) from a constructed PCOS-like endometrial organoid model.

Time Range

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Freshness

Last updated 2026-03-25 05:22:16; freshness should be verified.

Geography

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