Metabolic Syndrome and Chronic Pancreatitis Risk in UK Biobank Cohort

UK Biobank data from 349,995 participants tracked for a median of 18 years. The dataset, authored by Ruoyi Zhang and last updated in 2026, contains results from a prospective cohort study examining the association between metabolic syndrome and incident chronic pancreatitis.

Use Cases

• Assessing the dose-response relationship between metabolic syndrome components and disease risk based on the study's findings.
• Investigating the mediating role of systemic inflammation (e.g., via neutrophils and CRP) in disease pathways.
• Conducting subgroup analyses on risk factors for specific demographics (e.g., younger individuals, females) as described in the results.
• Validating hazard ratio models for chronic pancreatitis using the reported demographic, lifestyle, and clinical factors.

Strengths

• Large cohort size of 349,995 participants from the UK Biobank.
• Longitudinal design with a median follow-up of 18 years and 623 incident cases.
• Results include specific hazard ratios (e.g., HR 2.02 for MetS) and confidence intervals, allowing for quantitative analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying analysis data is unknown, which may limit suitability assessment.
• The primary file is a 37.1 KB DOCX document, suggesting the dataset is likely a summary table rather than the raw participant-level data.

Provenance

Source

UK Biobank

Collection Method

Prospective cohort study analyzing hospital admissions and death registry data using ICD codes.

Time Range

Median follow-up of 18 years (specific start/end years not provided).

Freshness

Last updated 2026-04-29 11:17:30; freshness should be verified.

Geography

United Kingdom