Rat Cerebral Cortex Transcriptome and Metabolome Profiles After Subarachnoid Hemorrhage

A 22.5 KB dataset from figshare, last updated in 2026, contains integrated transcriptomic and metabolomic profiles from the rat cerebral cortex following subarachnoid hemorrhage (SAH). It was created by Haoran Lu and includes data on differentially expressed genes and metabolites at 1-day and 7-day post-SAH time points. The dataset is licensed under CC-BY-4.0.

Use Cases

• Identify differentially expressed genes and metabolites based on the 982 DEGs and 540 DEMs reported between sham and SAH 1-day groups.
• Analyze immune and inflammatory pathway activation based on the description of Complement and coagulation cascades, TNF, and NOD-like receptor signaling pathways.
• Investigate metabolic pathway alterations based on the described changes in Arginine and proline, Arachidonic acid, and Folate biosynthesis pathways.
• Explore potential therapeutic targets for SAH based on the integration of transcriptomic and metabolomic signals described in the study.

Strengths

• Integrates two omics data types (transcriptome and metabolome) for a multi-faceted analysis of a disease model.
• Reports specific counts of differentially expressed entities: 982 DEGs and 540 DEMs at one time point, 292 DEGs and 254 DEMs at another.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.

Limitations

• Row count and column-level documentation are unknown, which limits suitability assessment and requires manual inspection after download.
• The dataset is very small (22.5 KB), indicating limited scope, likely containing summary results rather than raw sequencing or spectral data.
• Data is derived from a specific rat model, which may limit direct translation to human pathophysiology.

Provenance

Source

figshare, author Haoran Lu.

Collection Method

Data was generated using whole transcriptome sequencing and untargeted metabolomics assays on rat cerebral cortex tissue.

Time Range

Covers post-SAH time points of 1 day and 7 days compared to a sham group.

Freshness

Last updated 2026-04-28 14:40:41; freshness should be verified.