Metabolomic Shifts in Beef Steers Grazing Toxic Fescue

A metabolomics study from 2026 analyzed biological samples from 18 beef steers rotationally grazing toxic, novel, or endophyte-free tall fescue pastures. The dataset includes untargeted high-resolution metabolomics and targeted volatile fatty acid analysis results from urine, saliva, plasma, rumen fluid, and feces. It was authored by Ignacio M. Llada and shared under a CC-BY-4.0 license.

Use Cases

• Modeling metabolic pathway disruptions based on shifts in lipid and amino acid metabolism described in the results.
• Identifying biomarkers for fescue toxicosis based on discriminatory metabolites like tyramine and dopamine mentioned in the study.
• Studying the dynamics of alkaloid exposure and clearance based on the detection of clavine alkaloids and lysergic acid derivatives across matrices.
• Comparing metabolic recovery after toxic exposure based on the finding that previously exposed steers resembled never-exposed ones.

Strengths

• Includes data from five distinct biological matrices (urine, saliva, plasma, rumen fluid, feces) for a multi-faceted analysis.
• Study design involved 18 steers and a controlled crossover exposure protocol over two periods.
• Employs both untargeted high-resolution metabolomics and targeted gas chromatography-mass spectrometry analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a DOCX document (928.5 KB), which may require extraction of structured data.

Provenance

Source

figshare

Collection Method

Untargeted high-resolution metabolomics and targeted gas chromatography-mass spectrometry performed on samples from a controlled animal grazing study.

Freshness

Last updated 2026-05-15 07:22:16; freshness should be verified.