HIV Patient Coinfection Diagnostic Performance Comparison

Clinical data from 56 hospitalized people living with HIV with coinfections, comparing pathogen detection methods. The retrospective study was conducted by Xiaodi Li at the Third Affiliated Hospital of Sun Yat-sen University from March 2022 to October 2024. It evaluates the performance of metagenomic next-generation sequencing versus conventional testing methods.

Use Cases

• Compare mNGS and CTM detection_rates for Talaromyces marneffei and other pathogens using patient cohort data.
• Analyze the correlation between mNGS-guided therapy_adjustments and clinical_improvement outcomes.
• Study the prevalence of mixed_infections identified by different diagnostic methods across the patient sample.
• Evaluate diagnostic performance metrics, such as positive detection rates with confidence intervals, for each testing method.

Strengths

• Data includes 56 patient records with detailed diagnostic comparisons.
• Study reports statistically significant performance differences (p < 0.0001) between two diagnostic methods.
• Results cover a defined time range from March 2022 to October 2024.

Limitations

• Small sample size of 56 patients limits generalizability of findings.
• Dataset is very small at 25.2 KB, indicating limited raw data or a summary document.
• Retrospective study design may introduce selection bias.

Provenance

Source

Third Affiliated Hospital of Sun Yat-sen University.

Collection Method

Retrospective analysis of hospitalized patient records and diagnostic test results.

Time Range

March 2022 to October 2024.

Freshness

Data current through October 2024, with metadata last updated in April 2026.

Geography

Hospital in China (specific region unknown).