Microbiota and Metabolite Data from Coronavirus Mouse Study

17.4 KB Excel file contains tabular data from a multi-omics study on HCoV-OC43-infected mice. The dataset integrates 16S rRNA sequencing and metabolomic profiling to analyze intestinal microbiota and metabolic changes following MK-2206 antiviral treatment. Author Hanhan Feng published the data under CC BY 4.0 in March 2026.

Use Cases

• Analyze changes in Firmicutes and Actinobacteria phylum levels between MK-2206 and vehicle control treatment groups.
• Correlate the abundance of probiotic bacteria like Lactobacillus with viral load measurements from lung tissue.
• Investigate the relationship between increased succinic acid metabolite levels and reduced pathological changes in lung-intestine tissues.
• Model the combined antiviral effect using data on succinic acid abundance and MK-2206 treatment outcomes.

Strengths

• Data integrates two distinct analytical methods: 16S rRNA gene sequencing and non-targeted GC/LC-MS/MS metabolic profiling.
• Study design includes controlled treatment groups (MK-2206 vs. vehicle) for comparative analysis.
• Published under a permissive CC BY 4.0 license facilitating reuse.

Limitations

• Very small file size (17.4 KB) indicates limited data volume, likely summary results rather than raw sequencing or spectral data.
• Dataset scope is restricted to a single mouse model (HCoV-OC43-infected mice), limiting generalizability.
• Unknown row and column counts prevent assessment of dataset granularity and feature set.

Provenance

Source

Hanhan Feng via figshare.

Collection Method

Data generated from fecal samples of HCoV-OC43-infected mice treated with MK-2206 or vehicle, analyzed via 16S rRNA sequencing and metabolomics.

Time Range

null

Freshness

Last updated March 2026.

Geography

Laboratory mouse study, geographic origin unspecified.