Mouse and Human Data on Gut-Joint Immune Crosstalk in Arthritis

A 2.0 MB dataset by Eva Schmid, last updated on 2026-05-20, presents findings from a study on rheumatoid arthritis pathogenesis. The data, shared under a CC-BY-4.0 license on figshare, integrates mouse and human imaging mass cytometry and tissue sequencing to investigate early gut immune alterations prior to joint inflammation. It likely contains results linking intestinal endothelial changes, microbiota-specific IgG responses, and arthritis severity in a collagen-induced arthritis model.

Use Cases

• Modeling the temporal relationship between gut vascular permeability and synovial inflammation based on the described collagen-induced arthritis timeline.
• Analyzing microbiota-specific serum IgG responses to rare gut bacteria as described in the study's findings.
• Investigating the effects of gut-selective α4β7 integrin blockade or endothelial barrier enhancement on arthritis severity, as referenced in the experimental interventions.
• Spatial mapping of epithelial-immune interactions in ileal tissues based on the mentioned murine and human imaging mass cytometry data.

Strengths

• Integrates data from both mouse models and human tissues, as stated in the description.
• Includes spatial mapping from imaging mass cytometry, a high-plex technique mentioned in the study.
• Shared under a permissive CC-BY-4.0 license for broad reuse.

Limitations

• The dataset is small at 2.0 MB, which may limit the scope of included raw data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Likely contains results from imaging mass cytometry and tissue sequencing experiments in mouse and human studies, as described.

Freshness

Last updated 2026-05-20 05:44:24; freshness should be verified.