C. Elegans Mitochondrial Mutant Lifespan and FMO-2 Expression Data

Experimental data from a study on longevity pathways in C. elegans mitochondrial mutants. The dataset, authored by Jeremy M. Van Raamsdonk, contains results linking lifespan extension to the flavin-containing monooxygenase FMO-2. It is a 256.2 KB XLSX file released under a CC BY 4.0 license.

Use Cases

• Analyze the correlation between fmo-2 expression levels and lifespan extension in clk-1, isp-1, and nuo-6 mitochondrial mutants.
• Investigate the requirement of signaling molecules like HLH-30, NHR-49, and MDT-15 for fmo-2 upregulation in long-lived worms.
• Examine the role of genes such as DAF-16, PMK-1, and SKN-1 in regulating fmo-2 expression within the clk-1 mutant background.
• Compare the specificity of fmo-2 upregulation against other fmo genes across different genetic mitochondrial impairments.

Strengths

• Data is directly associated with a published scientific study on molecular mechanisms of longevity.
• Released under a permissive CC BY 4.0 license, facilitating open reuse and analysis.
• Focuses on specific, well-characterized C. elegans mitochondrial mutants (clk-1, isp-1, nuo-6) and the FMO-2 gene.

Limitations

• The dataset is small in scale at 256.2 KB, indicating limited data volume for large-scale statistical or machine learning modeling.
• The specific structure, column names, and row count are unknown, requiring inspection to understand the data format.
• Data is derived from a specific model organism (C. elegans), limiting direct applicability to mammalian or human aging studies without translation.

Provenance

Source

figshare, authored by Jeremy M. Van Raamsdonk.

Collection Method

Experimental data from genetic and RNA interference studies in C. elegans, as described in the accompanying publication.

Time Range

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Freshness

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Geography

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