Table 1: miR-21-5p Role in Hyperoxia-Induced Lung Injury

A 60.8 KB research document by Qianxia Huang, last updated in May 2026, details a study on hyperoxia-induced acute lung injury. The work identifies miR-21-5p as a regulator of ferroptosis via the YAP1 pathway, using in vitro and murine in vivo models. Findings suggest a potential regulatory mechanism for oxidative stress and cell death in lung tissue.

Use Cases

• Study the molecular mechanisms of hyperoxia-induced lung injury based on the described miR-21-5p/YAP1 axis.
• Investigate ferroptosis regulation in alveolar epithelial cells based on the described features of lipid peroxidation and iron accumulation.
• Validate interactions between microRNAs and target genes like YAP1 using the described dual-luciferase reporter assay results.
• Explore therapeutic targets for acute lung injury based on the described attenuation of injury via miR-21-5p restoration.

Strengths

• Document is under a permissive CC-BY-4.0 license for reuse.
• The description provides a detailed methodological and mechanistic background for the research.

Limitations

• The dataset is a single 60.8 KB DOCX file, indicating a very limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Likely contains experimental data from in vitro cell models and a murine in vivo model, as described in the methods.

Freshness

Last updated 2026-05-11 05:25:10; freshness should be verified.