Table 1_Modulation of monoaminergic neurotransmission in substance use disorders: a neurop

A 17.1 KB literature review document authored by Bhagavathi Sundaram Sivamaruthi and last updated on June 2, 2026. It summarizes recent preclinical and clinical data on transporter-modulating metabolites from specific plants and essential oils, integrating insights from structural biology and molecular pharmacology. The document is available under a CC-BY-4.0 license on figshare.

Use Cases

• Literature synthesis for identifying potential plant-derived compounds for adjunctive SUD therapy based on the described preclinical and clinical data.
• Hypothesis generation for molecular docking and dynamics simulations based on the discussed framework linking transporter structure to function.
• Informing experimental design for validating allosteric effects or downstream signaling pathways of essential oils mentioned in the review.

Strengths

• Specific focus on four plant sources (Hypericum perforatum L., Rhodiola rosea L., Withania somnifera, and some essential oils) for mechanistic insights.
• Integrates perspectives from structural biology, molecular pharmacology, and clinical data as described in the summary.
• Available under a permissive CC-BY-4.0 license for reuse and distribution.

Limitations

• The dataset is a 17.1 KB DOCX file, indicating a very limited textual scope rather than a primary data collection.
• Row count and column-level documentation are absent; the content structure must be inferred after download.
• The description notes that the effects of the discussed metabolites 'require further validation', indicating preliminary findings.

Provenance

Source

figshare

Collection Method

Authored literature review.

Freshness

Last updated 2026-06-02 05:40:17