Modulator-Induced Conformational Changes in Complement C5

A 124.5 KB document authored by Andrey Zhivnov and last updated in May 2026. It presents a systematic structural analysis of twelve complement C5-modulator complexes, comparing domain superposition, interface quantification, and conformational analysis. The findings provide a structural framework for the rational design of next-generation complement therapeutics.

Use Cases

• Benchmarking inhibitor mechanisms based on conformational perturbation analysis.
• Informing rational drug design based on the identified structural framework.
• Studying the relationship between domain rigidity and global constraint redistribution in proteins.

Strengths

• Analysis is based on twelve distinct C5-modulator complexes, allowing for systematic comparison.
• The document is licensed under CC-BY-4.0, permitting open sharing and adaptation.

Limitations

• The dataset is a 124.5 KB DOCX file, indicating a limited scope of textual analysis rather than raw structural data.
• Column-level documentation is absent; field semantics must be inferred from the text.
• Row count is unknown, which may limit suitability assessment for computational reuse.

Provenance

Source

figshare

Collection Method

Systematic comparison of twelve C5-modulator complexes using domain superposition, interface quantification, and conformational analysis.

Freshness

Last updated 2026-05-15 05:47:23.