Molecular Epidemiology of Carbapenem-Resistant Klebsiella Pneumoniae in South China

108 carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates from hospitals in South China, analyzed by Yuting He in 2026. The dataset includes whole-genome sequencing results on antimicrobial resistance genes, virulence factors, and phylogenetic relationships. It documents the prevalence of specific sequence types, serotypes, and resistance mechanisms like KPC-2.

Use Cases

• Phylogenetic analysis of CRKP strains based on whole-genome sequencing data.
• Tracking the prevalence of specific carbapenemase types like KPC-2 and KPC-12.
• Studying the co-occurrence of hypervirulence markers (e.g., iuc1, ybt9) with multi-drug resistance.
• Identifying mutations associated with fluoroquinolone resistance (e.g., GyrA-83I).
• Monitoring the emergence of novel high-risk clones like ST413-1LV-KL112 hvCRKP.

Strengths

• Includes 108 clinically relevant bacterial isolates.
• Analyzes multiple genetic factors: resistance genes, virulence factors, and porin/efflux pump mutations.
• Identifies 17 hypervirulent CRKP (hvCRKP) strains.
• Reports on a rarely reported KPC-2 variant (KPC-12) found in four strains.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is limited to a specific region (South China) and time period.

Provenance

Source

Yuting He via figshare.

Collection Method

Retrospective study of 108 CRKP isolates collected from multiple hospitals, analyzed via whole-genome sequencing and Kleborate software.

Time Range

null

Freshness

Last updated 2026-04-16 05:25:58; freshness should be verified.

Geography

South China