Mouse Models for Post-Sepsis Syndrome: Cecal Slurry vs. Cecal Ligation and Puncture

John-Matthew K. Ang published a dataset on 2026-05-22 comparing murine models for studying Post-Sepsis Syndrome (PSS). The data likely contains results from a study with 7 experimental groups, including survival rates and IL-6 measurements at 6 hours and 1 month post-sepsis induction. The 818.1 KB file is available under a CC-BY-4.0 license on figshare.

Use Cases

• Comparing survival outcomes between cecal slurry injection and cecal ligation and puncture mouse models based on the described study groups.
• Analyzing persistent inflammatory markers like plasma IL-6 levels one month after sepsis induction.
• Evaluating the suitability of different surgical models for studying chronic Post-Sepsis Syndrome based on described cecum abnormalities and IL-6 gene expression.

Strengths

• The study design includes 7 distinct control and experimental groups, allowing for comparative analysis.
• Specific quantitative results are described, such as survival rates of 73–78% and acute plasma IL-6 levels ranging from 63.3 to 159.6 pg/mL.
• The dataset is associated with a detailed methodological description of the animal procedures and sample collection.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small at 818.1 KB, indicating a limited scope of data.

Provenance

Source

John-Matthew K. Ang

Collection Method

Experimental data from a controlled mouse study comparing sepsis models, involving surgical procedures, blood sampling, and tissue analysis.

Freshness

Last updated 2026-05-22 05:36:30; freshness should be verified.