Mouse TAPBPR Functional Analysis: MHC-I Immunopeptidome Shaping in MC-38 Cells

Mouse TAPBPR interaction data reveals its role as a peptide exchange catalyst for MHC-I molecules H2-Db and H2-Kb. The 6.0 MB dataset, authored by Juliana Bernardi Aggio and last updated in April 2026, compares mouse TAPBPR function to its human counterpart. Findings suggest mouse TAPBPR restricts and edits the peptide repertoire, promoting selection of peptides with C-terminal methionine on H2-Kb.

Use Cases

• Compare peptide editing functions between mouse and human TAPBPR based on the described functional similarity.
• Analyze MHC-I binding partner preferences based on the sustained interaction with H2-Db compared to H2-Kb.
• Investigate peptide repertoire restriction on H2-Db and H2-Kb molecules in MC-38 cells as described.
• Model the selection of peptides with C-terminal methionine on H2-Kb promoted by mouse TAPBPR presence.

Strengths

• Data is licensed under CC-BY-4.0, allowing for open reuse and modification.
• File size is 6.0 MB, indicating a manageable download and analysis scale.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

figshare

Collection Method

Experimental characterization of mouse TAPBPR in cell lines, as described.

Time Range

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Freshness

Last updated 2026-04-15 04:21:55; freshness should be verified.

Geography

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