Fabry Disease Cytokine Levels and Vestibular/Oculomotor Dysfunction

40 Fabry disease patients were enrolled in a prospective observational study, with plasma concentrations of 14 inflammatory cytokines measured. The data, authored by Yinglin Leng and last updated in April 2026, shows statistical correlations between cytokine levels and specific vestibular/oculomotor abnormalities. Results indicate associations for cytokines like TNF-β, IL-2, and IL-17A with measured dysfunctions.

Use Cases

• Correlate inflammatory cytokine levels with saccade latency and accuracy based on TNF-β measurements.
• Analyze differences in cytokine profiles between patients with and without vestibulo-oculomotor dysfunction based on IL-2, IL-17A, and TNF-β levels.
• Investigate the relationship between IL-12p70 levels and defective pursuit in visuo-oculomotor examinations.
• Model the association between TNF-β-related pathways and central/peripheral vestibular dysfunction in Fabry disease patients.

Strengths

• Data is from a prospective, longitudinal study design involving 40 patients.
• Plasma concentrations of 14 specific inflammatory cytokines were measured, including interferon-γ, multiple interleukins, and tumor necrosis factors.
• Statistical analyses include p-values and correlation coefficients (e.g., r=0.378) for relationships between cytokines and clinical measures.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small atscale (23.1 KB), indicating limited scope.

Provenance

Source

figshare, author Yinglin Leng.

Collection Method

Prospective observational study; plasma cytokine detection and clinical examinations.

Freshness

Last updated 2026-04-17 05:19:43; freshness should be verified.