94.44% of 18 esophageal squamous cell carcinoma (ESCC) samples showed TP53 mutations via whole-exome and whole-genome sequencing. The dataset, published by Xueyu Zhuang in 2026, compares these genetic mutations with mutant p53 protein expression detected by immunohistochemistry. It reports a 100% sensitivity and specificity for mutant p53 expression in diagnosing ESCC across 78 total patient samples.
Use Cases
- Validate mutant p53 expression as a diagnostic marker for ESCC based on the reported 100% sensitivity and specificity.
- Analyze the association between TP53 gene mutations and p53 protein expression patterns mentioned in the study.
- Compare the five mutant p53 expression subtypes identified across different patient cohorts.
- Assess interobserver consistency in pathological assessment using the reported Kappa coefficient of 0.954.
Strengths
- Includes data from 78 total patient samples (18 for sequencing, 60 for IHC).
- Reports high concordance (94.44%) between TP53 mutation and mutant p53 protein expression.
- Provides specific statistical metrics, including sensitivity, specificity, and a Kappa coefficient for interobserver agreement.
Limitations
- Row count is unknown, which may limit suitability assessment.
- Column-level documentation is absent; field semantics must be inferred after download.
- The dataset is very small (10.6 KB), indicating limited scope and sample size.
Provenance
- Source
- figshare, author Xueyu Zhuang.
- Collection Method
- Data collected from whole-exome sequencing, whole-genome sequencing, and immunohistochemical staining of patient tissue samples.
- Freshness
- Last updated 2026-03-18 07:35:02; freshness should be verified.