Naringenin Effects on Vascular Calcification and Senescence via p53/TOP2A

A research document from figshare details the inhibitory effects of naringenin on vascular calcification and senescence in chronic kidney disease. The study used human vascular specimens, cultured vascular smooth muscle cells, and a rat model, with results last updated in May 2026. The 21.1 KB DOCX file contains findings from histological staining, RNA sequencing, and molecular assays.

Use Cases

• Study the association between vascular calcification and senescence based on findings from patient tissues, cultured cells, and rat models.
• Investigate the mechanism of naringenin's protective effects based on transcriptomic analysis implicating the p53 pathway and TOP2A.
• Validate molecular interactions based on results from chromatin immunoprecipitation and dual-luciferase assays described in the document.

Strengths

• Document is licensed under CC-BY-4.0, allowing for open sharing and adaptation.
• Research methodology is described in detail, including multiple experimental approaches like RNA sequencing and molecular docking.

Limitations

• The dataset is a 21.1 KB DOCX file, indicating a limited scope primarily containing textual results rather than raw experimental data.
• Row count and column-level documentation are absent, requiring manual inspection to understand data structure.
• The upstream mechanism for p53 suppression is noted as unclear in the conclusion.

Provenance

Source

Author Xiaoya Tong via figshare.

Collection Method

Experimental research using human specimens, cell cultures, and a rat model, with analysis via staining, sequencing, and molecular assays.

Time Range

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Freshness

Last updated 2026-05-08 05:55:51.

Geography

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