Table 1_NAT2 rs1495741 and anti-tuberculosis drug-induced liver injury in children: geneti

192 children receiving anti-tuberculosis treatment, including 31 with drug-induced liver injury (ATB-DILI) and 161 without, were studied for genetic associations. The dataset includes results from testing 86 single-nucleotide polymorphisms, with NAT2 rs1495741 showing a significant association with ATB-DILI risk. It was authored by Xin Huang and last updated on 2026-05-08.

Use Cases

• Assessing the association between NAT2 rs1495741 genotypes and ATB-DILI risk based on the reported odds ratios.
• Developing predictive models for ATB-DILI risk in children by integrating genetic and clinical variables as described.
• Evaluating the concordance between rs1495741 and inferred NAT2 acetylator phenotypes using the reported Cohen's kappa statistic.
• Analyzing the relationship between rs1495741 genotype and measured 2-hour plasma isoniazid concentration.

Strengths

• Includes data from 192 pediatric patients, a specific cohort for a condition with limited pediatric evidence.
• Reports statistically significant findings, such as a 7.29-fold higher risk for the AA genotype and an AUC of 0.874 for the best predictive model.
• Contains genetic data on 86 tested single-nucleotide polymorphisms and inferred NAT2 diplotypes.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small at 22.9 KB, indicating a limited scope focused on a specific genetic variant and clinical outcome.

Provenance

Source

figshare, author Xin Huang.

Collection Method

Clinical and genetic association study of children receiving anti-tuberculosis treatment.

Freshness

Last updated 2026-05-08 07:43:38; freshness should be verified.