Oliceridine vs. Morphine: Meta-Analysis of Postoperative Nausea and Vomiting from 5 RCTs

Jinfang Zeng's systematic review and meta-analysis, published on figshare in 2026, aggregates data from five randomized controlled trials with 1,767 patients. It compares the incidence of postoperative nausea, vomiting, and other opioid-related adverse events between the analgesic oliceridine and morphine. The analysis includes dose-specific risk ratios for 0.1 mg, 0.35 mg, and 0.5 mg oliceridine groups.

Use Cases

• Compare the relative risk of postoperative nausea between oliceridine and morphine based on the pooled risk ratios.
• Analyze dose-response relationships for adverse events using the dose-specific subgroup analyses for 0.1 mg, 0.35 mg, and 0.5 mg groups.
• Evaluate the safety profile of oliceridine for side effects like dizziness, dry mouth, pruritus, and somnolence based on the reported risk ratios.
• Assess the certainty of evidence for clinical outcomes using the referenced GRADE system ratings.

Strengths

• Includes data from 1,767 patients across five randomized controlled trials, providing a quantitative basis for analysis.
• Reports specific risk ratios and 95% confidence intervals for multiple outcomes (nausea, vomiting) and dose subgroups.
• Follows a systematic review methodology with a registered protocol (PROSPERO CRD42024604703).

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small at 11.2 KB, indicating limited scope and likely summary-level data rather than patient-level records.
• The certainty of evidence for the findings, as noted in the description, ranges from moderate to low.

Provenance

Source

Jinfang Zeng via figshare.

Collection Method

Systematic review and meta-analysis of randomized controlled trials from PubMed/MEDLINE, Embase, and Cochrane CENTRAL up to September 2025.

Time Range

Trials from database inception up to 30 September 2025.

Freshness

Last updated 2026-04-22 05:49:38.