Neonatal Jaundice and Gut Microbiome Data from a Xinjiang Case-Control Study

A 9.8 KB dataset from a case-control study of term infants with pathologic jaundice and matched healthy controls in Xinjiang, published by Muqing Niu on figshare in March 2026. It contains results from shotgun metagenomic sequencing of stool samples, including microbial diversity, taxonomic composition, and functional gene repertores, used in a bidirectional Mendelian randomization analysis.

Use Cases

• Train models to classify jaundiced infants based on gut microbiome beta diversity and Bray-Curtis dissimilarity.
• Analyze the relationship between specific microbial taxa (e.g., Escherichia coli, Bifidobacterium) and neonatal jaundice risk.
• Investigate the functional role of microbial pathways in bile acid synthesis and carbohydrate metabolism in jaundice.
• Perform causal inference studies using the Mendelian randomization framework applied to microbiome traits.

Strengths

• Dataset is openly licensed under CC-BY-4.0.
• Analysis includes both shotgun metagenomic sequencing and bidirectional Mendelian randomization, a multi-method approach.
• Description provides specific findings on microbial taxa and functional pathways associated with jaundice.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• The dataset is very small at 9.8 KB, indicating it likely contains summary results rather than raw sequencing data.
• Geographic coverage is limited to a single region (Xinjiang), which may affect generalizability.

Provenance

Source

figshare, author Muqing Niu.

Collection Method

Stool samples from a case-control study were subjected to shotgun metagenomic sequencing; publicly available GWAS summary statistics were used for Mendelian randomization.

Freshness

Last updated 2026-03-18 07:36:17.

Geography

Xinjiang