Neurofilament Light Chain and Motor Function in Myotonic Dystrophy Type 1

33 patients with myotonic dystrophy type 1 and 31 controls were studied to evaluate plasma neurofilament light chain as a biomarker. The dataset, authored by Chul Hwi Shin and last updated in May 2026, shows significant correlations between NfL levels and clinical motor function scores. It likely contains patient-level data on biomarker levels, clinical assessments, and demographic variables.

Use Cases

• Correlating biomarker levels with disease severity based on the Muscular Impairment Rating Scale (MIRS) scores mentioned in the description
• Analyzing the relationship between neurofilament light chain and functional capacity based on 6-minute walk test performance
• Investigating the association between disease duration and biomarker levels as described in the results
• Developing predictive models for motor impairment in DM1 based on plasma NfL and clinical variables

Strengths

• Includes data from 33 DM1 patients and 31 controls, providing a case-control comparison.
• Clinical assessments include specific, validated measures like the MIRS and 6MWT.
• Analysis methods, including partial correlation based on Kendall's Tau, are described.

Limitations

• The dataset is very small at 20.0 KB, indicating limited scope and sample size.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare, author Chul Hwi Shin

Collection Method

Clinical study enrolling patients and controls, with plasma biomarker measurement and motor function assessment.

Freshness

Last updated 2026-05-26 07:59:59; freshness should be verified.