NIID Case Report: Intractable Nausea and Vomiting Responsive to Corticosteroids

A single clinical case report documents a 61-year-old female patient with a 22-year history of drug-refractory nausea and vomiting later diagnosed as Neuronal Intranuclear Inclusion Disease (NIID). The report details diagnostic findings from diffusion-weighted imaging, genetic analysis of the NOTCH2NLC gene, and skin biopsy, along with the patient's response to corticosteroid therapy over a six-month follow-up. The dataset, a 19.1 KB DOCX file, was authored by Long Luo and published on figshare under a CC-BY-4.0 license.

Use Cases

• Study the clinical presentation of NIID based on the detailed case history of intractable nausea and vomiting.
• Analyze diagnostic criteria for NIID based on described MRI findings, genetic testing, and biopsy results.
• Investigate treatment responses in NIID based on the documented patient outcome with corticosteroid therapy.
• Support literature reviews on rare disease case studies based on the structured clinical narrative.

Strengths

• Case includes specific diagnostic details: a 'crown-like' hyperintensity on MRI and a GGC repeat expansion in NOTCH2NLC gene.
• Documents a clear, long-term (22-year) patient history and a six-month treatment follow-up period.
• Published under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.

Limitations

• Dataset is a single case report (19.1 KB), representing an extremely limited sample size.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect reporting bias inherent to a single, published case study.

Provenance

Source

figshare

Collection Method

Clinical case documentation and reporting.

Time Range

Case history spans 22 years, with a six-month documented follow-up.

Freshness

Last updated 2026-03-18 06:42:11; freshness should be verified.