Pakpunavirus vB_Pa_AN-12: Efficacy and Safety Assessment for P. aeruginosa Skin Infections

A research document describes the newly isolated phage vB_Pa_AN-12, a member of the Pakpunavirus genus, and its assessment for phage therapy against Pseudomonas aeruginosa skin infections. The document, authored by Agnieszka Necel and last updated in April 2026, details the phage's ability to infect multiple antibiotic-resistant clinical strains and its safety profile on human cell lines. The file is a 674.5 KB DOCX document shared under a CC-BY-4.0 license on figshare.

Use Cases

• Evaluating phage therapy candidates based on the described efficacy against multiple antibiotic-resistant P. aeruginosa strains.
• Assessing phage safety for human applications based on the described lack of harmful genes and non-toxicity to keratinocyte, fibroblast, and monocyte cell lines.
• Studying phage-host interaction dynamics based on the described reduction of host cell viability by 5 logs in 1 hour and production of about 100 progeny virions per infected cell.
• Designing combination therapy strategies based on the suggestion to investigate the phage alongside other antimicrobials to counter potential resistance development.

Strengths

• The description provides specific quantitative efficacy metrics, including a 5-log reduction in host cell viability in 1 hour.
• The description provides specific quantitative production metrics, stating about 100 progeny virions per infected cell.
• The description includes concrete safety assessments on three specific human cell lines (HaCaT, BJ, SC).
• The dataset is openly licensed (CC-BY-4.0) for reuse.

Limitations

• The dataset is a 674.5 KB DOCX document, which is a small text file; the scope is limited to the described research findings.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for structured data analysis.

Provenance

Source

figshare

Collection Method

Research findings from phage isolation and laboratory characterization.

Time Range

The document was last updated in April 2026; the temporal coverage of the underlying research is not specified.

Freshness

Last updated 2026-04-20 05:22:40; freshness should be verified.

Geography

Spatial coverage is not specified.