NFYC-KLF1-LDHA Transcriptional Pathway in Glioblastoma Cells

A research study investigating the NFYC-KLF1-LDHA transcriptional axis driving glycolysis and tumor growth in glioblastoma multiforme (GBM). Yan Fang authored the study, which was last updated on April 9, 2026. The data likely includes bioinformatic analysis results from The Cancer Genome Atlas and experimental results from cell line and xenograft models.

Use Cases

• Identify transcriptional regulators of LDHA based on bioinformatic analysis of TCGA glioma data
• Model the NFYC-KLF1-LDHA regulatory pathway based on ChIP and luciferase assay results
• Assess the impact of gene knockdown on glycolytic flux and mitochondrial metabolism based on Seahorse analysis data
• Evaluate the correlation between LDHA expression and patient prognosis based on TCGA analysis

Strengths

• The study integrates multiple experimental methods, including bioinformatics, cell line assays, and xenograft models
• Data is openly available under a CC-BY-4.0 license
• The research identifies a specific hierarchical transcriptional pathway (NFYC-KLF1-LDHA)

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is a single 21.6 KB document, suggesting limited scope

Provenance

Source

figshare

Collection Method

Bioinformatic analysis of The Cancer Genome Atlas data combined with laboratory experiments on glioblastoma cell lines and xenograft models.

Freshness

Last updated 2026-04-09 05:20:22