NGF Administration Effects on GnRH and Hormone Levels in Aging Mice

Experimental data from a study on nerve growth factor (NGF) administration in male SAMP8 mice. The dataset likely contains measurements of serum hormone levels (LH, FSH, testosterone) over time and immunofluorescence readouts for GnRH and Sox2. The data was authored by Jiao Luo and uploaded to figshare in April 2026 under a CC-BY-4.0 license.

Use Cases

• Analyze the time-course effects of NGF on serum hormone levels based on measurements taken at 8h, 24h, 96h, 7d, and 10d post-injection.
• Investigate the relationship between NGF administration and GnRH immunoreactivity based on phenotypic readouts from the OVLT brain region.
• Study the differentiation of hypothalamic neural stem cells into a GnRH-associated phenotype based on in vitro culture results.
• Examine signaling pathways involved in NGF's effects based on transcriptomic profiling and qPCR data mentioned in the description.

Strengths

• Data is associated with a detailed methodological description covering in vivo and in vitro experiments.
• The dataset is published under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The dataset is very small (14.6 KB), indicating limited scope and likely a summary or key results table rather than raw experimental data.

Provenance

Source

figshare

Collection Method

Data originates from a laboratory study involving mouse models, hormone assays, immunofluorescence, and cell culture.

Freshness

Last updated 2026-04-24 05:40:48; freshness should be verified.