Table 1_Non-anticoagulant heparin attenuates histone-mediated platelet–leukocyte aggregati

Eleven healthy dogs provided blood samples for an in vitro study of sepsis and systemic inflammation. The dataset likely contains flow cytometry measurements of platelet-leukocyte aggregates and neutrophil extracellular trap (NET) formation after treatment with non-anticoagulant heparin (NACH) and unfractionated heparin (UFH). Maria A. Guzmán authored this research data, which was last updated on April 15, 2026.

Use Cases

• Compare the efficacy of non-anticoagulant heparin versus unfractionated heparin based on aggregate reduction percentages.
• Model stimulus-specific anti-inflammatory effects based on responses to histone versus E. coli challenges.
• Analyze dose-response relationships for heparin treatments based on the concentration levels tested.
• Investigate correlations between platelet-leukocyte aggregates and neutrophil citrullinated histone H3 expression.

Strengths

• Data is derived from a controlled in vitro model using blood from 11 healthy dogs.
• Includes specific quantitative results, such as a 29.0% reduction in histone-induced platelet-leukocyte aggregates with NACH at 10 μg/mL.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• The dataset is very small at 28.7 KB, indicating limited scope.
• Data is contained within a DOCX file, which may require extraction for analysis.

Provenance

Source

figshare

Collection Method

Whole blood was collected from staff-owned dogs and incubated with histones or E. coli; measurements were taken via flow cytometry.

Time Range

The experimental timeframe is not specified.

Freshness

Last updated 2026-04-15 04:36:31.

Geography

The geographic origin of the dogs or study location is not specified.