Table 1_Non-invasive molecular surveillance of drug-resistant bacterial and fungal pathoge

A prospective cohort study from January 1 to July 30, 2024, collected paired nasopharyngeal swab and bronchoalveolar lavage fluid samples from 105 ICU patients with severe pneumonia. The dataset, authored by Hua Li and shared under a CC-BY-4.0 license, compares pathogen detection using targeted next-generation sequencing, with longitudinal sampling performed on a subset of 74 patients. It includes performance metrics like positive and negative percent agreement for various bacterial, viral, and fungal pathogens.

Use Cases

• Compare detection sensitivity of nasopharyngeal swabs versus bronchoalveolar lavage fluid for specific pathogens like Acinetobacter baumannii and Staphylococcus aureus based on the described concordance metrics.
• Assess the utility of non-invasive sampling for early antimicrobial decision-making in ICU pneumonia based on the described high concordance for major bacterial pathogens.
• Investigate temporal changes in pathogen profiles for longitudinal surveillance based on the two-phase sampling described for 74 patients.
• Evaluate the performance of molecular diagnostics for fungal and viral pathogens in severe pneumonia based on the variable sensitivity results described.

Strengths

• Includes paired samples from 105 patients, allowing for direct comparison between invasive and non-invasive diagnostic methods.
• Provides specific performance metrics, including positive percent agreement ≥80.0% for major bacterial pathogens and negative percent agreement exceeding 95.0%.
• Contains longitudinal data from two-phase sampling in a subset of 74 patients to assess temporal pathogen dynamics.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small in scale at 248.4 KB, indicating limited scope.

Provenance

Source

figshare, author Hua Li

Collection Method

Prospective cohort study with sample collection and targeted next-generation sequencing.

Time Range

January 1, 2024 to July 30, 2024

Freshness

Last updated 2026-04-22 05:48:15; freshness should be verified.