Meta-Analysis of Lactated Ringer's vs. Normal Saline for Acute Pancreatitis

A 301.6 KB systematic review and meta-analysis document compares lactated ringer’s (LR) and normal saline (NS) for fluid resuscitation in acute pancreatitis. The analysis, conducted by Weijun Jiang and published on figshare in 2026, includes studies from PubMed, Web of Science, Embase, CNKI, and WanFang up to July 2025. Primary outcomes assessed were mortality, systemic inflammatory response syndrome (SIRS), ICU transfer, pancreatic necrosis, organ failure, and hospital length of stay (LOS).

Use Cases

• Comparing mortality outcomes between LR and NS based on the reported odds ratio (OR = 1.020).
• Analyzing hospital length of stay (LOS) differences in specific subgroups like RCTs or severe acute pancreatitis (SAP) patients based on standardized mean difference (SMD) results.
• Evaluating trends in organ failure outcomes based on the reported non-significant odds ratio (OR = 0.563).
• Assessing the heterogeneity of results across study designs (RCT vs. non-RCT) and sample sizes mentioned in the analysis.

Strengths

• Follows PRISMA 2020 guidelines for systematic review and meta-analysis methodology.
• Reports specific statistical results, including odds ratios (OR), confidence intervals (CI), and p-values for multiple clinical outcomes.
• Includes trial sequential analysis to confirm true negative findings for some outcomes and indicate insufficient power for others.

Limitations

• The dataset is a 301.6 KB DOCX document; the underlying tabular meta-analysis data (rows, columns) is not directly available.
• Column-level documentation is absent; field semantics must be inferred from the manuscript text after download.
• High heterogeneity was noted in non-RCT and large-sample subgroups, which may affect result generalizability.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of studies from PubMed, Web of Science, Embase, CNKI, and WanFang.

Time Range

Literature search conducted until July 2025.

Freshness

Last updated 2026-05-08 05:56:29; includes literature search up to July 2025.