Macrophage Immune Responses to 12 Clinical Group B Streptococcus Isolates

A figshare-hosted dataset by Larisa Janžič, last updated April 2026, under a CC-BY-4.0 license. It contains experimental results quantifying human macrophage responses to 12 distinct clinical Group B Streptococcus isolates, measuring cytokine production, caspase-1 activity, and gene expression at multiple time points.

Use Cases

• Classifying bacterial strain virulence based on macrophage cytokine and inflammasome activation profiles described in the results.
• Modeling temporal dynamics of host immune responses using the 3, 4, and 24-hour post-infection measurements mentioned.
• Investigating associations between immunoregulatory markers like IL-10 and metabolic genes like ACOD1 as indicated in the integrated analysis.
• Stratifying bacterial isolates by clinical metadata such as serotype and neonatal gestational age to link strain traits to disease outcomes.

Strengths

• Data is derived from 12 fully characterized clinical isolates representing multiple serotypes and sequence types.
• Multidimensional measurements include cytokine/chemokine quantification, caspase-1 activity, and gene expression for inflammatory, immunoregulatory, metabolic, and cell death pathways.
• Includes temporal resolution with measurements taken at early (3/4 hours) and later (24 hours) time points post-infection.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small in scale at 733.7 KB, indicating limited data volume.

Provenance

Source

figshare

Collection Method

Experimental data from in vitro infection of human THP-1 macrophages with bacterial isolates, analyzed using LEGENDplex immunoassays, bioluminescence, and RT-qPCR.

Time Range

Experimental time points are 3, 4, and 24 hours post-infection.

Freshness

Last updated 2026-04-16 05:17:03; freshness should be verified.

Geography

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